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Sze-Kwan Lin Acting Chairman&Professor

Acting Chairman of Department of Dentistry, NTU. Acting Associate Director of Department of Dentistry, NTUH

Tel:886-2-23123456 ext 67400
Email:sklin7400@ntu.edu.tw


Experiences

BDS, National Taiwan University, 1986
M.S., National Taiwan University, 1992
Ph.D., National Taiwan University , 2000

Diplomate of Academy of Endodontology, ROC

Professional specialties

Endodontic surgery

Main Research Interests

The pathogenesis and potential therapeutic stratiges of rheumatoid arthritis (RA)

  1. Mechanisms regulating the expression of potential pathogenic mediators in synovial fibroblasts and osteoblast including: signal transduction, transcriptional regulation, transcription factor/promoter interactions
  2. In vitro/in vivo correlation: A murine model of collagen-induced arthritis (CIA) were established. The role of pathogenic mediators in disease progression will be detected as listed.
    a. the over-expressed or small hairpin (sh)RNA of the candidate genes will be constructed into lentivirus. These genes will be delivered to CIA rats via viral vectors.
    b. nano-technique for more efficient gene delivery will also be developed.
    c. transgenic mice targeting the potential mediators from I-1 will be established. 
  3. To substantiate the impact of the candidate molecules on RA development, the progression of CIA in groups“a”,“b”,“c”will be assessed by image analysis (X-ray or computer tomography) and immunohistochemistry. The results may help elucidating the therapeutic potentials of RA.

Animal models of some commonly encountered dental diseases such as chronic apical periodontitis and biphosphonate-related osteonecrosis of the jaw (BRONJ) will be developed. The expressions of the mediators identified from I-1 will be detected.
Collaborations

  1. Dr. Jenny Ting:
    Alumni Distinguished Professor of Microbiology-Immunology
    Immunology Program Leader, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina, USA
  2. Dr. Steven Goldring:
    Beth Israel Deaconess Medical Center, Harvard Institute of Medicine, Boston, USA.
  3. Dr. Michael Hsiao:
    Genomics Research Center, Academia Sinica, Taipei, Taiwan
  4. Dr. CT Shun:
    Department of Pathology, National Taiwan University Hospital, Taipei,Taiwan
  5. Dr. Chang CC:
    Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan
  6. Dr. Chou HYE:
    Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan

Selected Publications

  1. Hou KL, Lin SK, Kok SH, Wang HW, Lai EHH, Hong CY, Yang H, Wang JS, Lin LD and Chang JZC (2017). Increased Expression of Glutaminase in Osteoblasts Promotes Macrophage Recruitment in Periapical Lesions. Journal of Endodontics 43: 602-608. (SCI)
  2. Hou KL, Lin SK, Chao LH, Hsiang-Hua Lai E, Chang CC, Shun CT, Lu WY, Wang JH, Hsiao M, Hong CY and Kok SH (2017). Sirtuin 6 suppresses hypoxia-induced inflammatory response in human osteoblasts via inhibition of reactive oxygen species production and glycolysis-A therapeutic implication in inflammatory bone resorption. Biofactors 43: 170-180. (SCI)
  3. Kok SH, Hou KL, Hong CY, Chao LH, Lai HH, Wang HW, Yang H, Shun CT, Wang JS, Lin SK (2015). Sirtuin 6 modulates hypoxia-induced apoptosis in osteoblasts via inhibition of glycolysis: implication for pathogenesis of periapical lesions. Journal of Endodontics 41(10):1631-7. (SCI)
  4. Kok SH, Lin LD, Hou KL, Hong CY, Chang CC, Hsiao M, Wang JH, Lai EHH, Lin SK (2013). Simvastatin inhibits cysteine-rich protein 61 expression in rheumatoid arthritis synovial fibroblasts through the regulation of sirtuin-1/FoxO3a signaling. Arthritis & Rheumatology 65: 639-649. (SCI)
  5. Chang CC, Yang MH, Lin BR, Chen ST, Pan SH, Hsiao M, Lai TC, Lin SK, Jeng YM, Chu CY, Chen RH, Yang PC, Eugene Chin Y, Kuo ML (2013). CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation. Cell Death and Differentiation 20(3):443-55. (SCI)
  6. Lai EHH, Hong CY, Kok SH, Hou KL, Chao LH, Lin LD, Chen MH, Wu PH, Lin SK (2012). Simvastatin Alleviates the Progression of Periapical Lesions by Modulating Autophagy and Apoptosis in Osteoblasts. Journal of Endodontics 38(6):757-63. (SCI)
  7. Yang MH, Lin BR, Chang CH, Chen ST, Lin SK, Kuo MYP, Jeng YM, Kuo ML, Chang CC (2012). Connective tissue growth factor modulates oral squamous cell carcinoma invasion by activating a miR-504/FOXP1 signalling. Oncogene 31(19):2401-11. (SCI)
  8. Shun CT, Lin SK, Kok SH, Hong CY, Wang JS, Yang H, Lai EHH, Lai JY, Liu CM (2011). Hypoxia induces cysteine-rich 61 expression in human nasal polyp fibroblasts: an implication for the pathogenesis of nasal polyposis. American Journal of Rhinology (Accepted). (SCI)
  9. Lee YL, Lin SK, Hong CY, Wang JS, Yang H, Lai EHH, Chen MH, Kok SH (2010). Major Histocompatibility Complex Class II Transactivator Inhibits Cysteine-rich 61 Expression in Osteoblastic Cells and Its Implication in the Pathogenesis of Periapical Lesions. Journal of Endodontics 36(6):1021-25. (SCI)
  10. Kok SH, Hou KL, Hong CY, Wang JS, Liang PC, Chang CC, Hsiao M, Yang H, Lai EH, Lin SK (2010). Simvastatin inhibits cytokine-stimulated Cyr61 expression in osteoblastic cells: A therapeutic benefit for arthritis. Arthritis and Rheumatism:Epub ahead of print. (SCI)

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