BDS, National Taiwan University, 1989
Ph.D., Oral Biology, University of California San Francisco, 1997
Certificate, Postgraduate in Orthodontics at UCSF, 1999
Orthodontics, oral biology, cell biology
Main Research Interests
Tissue and cellular reaction to mechanical stimulation
1. Distraction Osteogenesis:
Most of orthodontic patients require only dental movements to correct their malocclusion. However, severe sagittal jaw discrepancy found in some patients with craniofacial anomalies has to rely on orthognathic surgery to correct this jaw size problem. Recently, distraction osteogenesis has become a choice to treat patients with severe skeletal discrepancy for better stability with larger degree of advancement. However, we know little of mechanisms of soft tissue response following distraction osteogenesis besides bone can grow in the osteotomy sites in head region. Therefore, the adjacent soft tissues especially facial muscles would affect the extent and stability of mandibular distraction osteogenesis. In this study, miniature pigs are used as an animal model to study facial muscles with two different fiber orientations following mandibular distraction. Our ultimate goal is to develop ways to augment soft tissues besides bone structures with mechanical stimulation from distraction osteogenesis.
2. Cellular response to force stimulation:
Cellular response to force is essential for tooth movement which involves bone resorption, bone deposition and sometimes unwanted root resorption that may or may not repaired with cellular cementum. Therefore, we would like to characterize cells mediating root resorption and signals and changes of cells induced by different mechanical stimulation. The specific aims are as follows: 1) Build up mouse model. 2) Identification cell origin for root resorption. 3) Response of PDL and bone cells at compression side vs. tension side. Our long-term goal is to apply this knowledge to treatment for speeding up the rate of orthodontic tooth movement without damages to the roots.
Stability of temporary anchorage devices (TADs)
Animal studies are used to explore the parameters that influence stability of TADs and the consequences of contacting the root and the repairing mechanism.
- Yao CC, Chang HH, Chang JZ, Lai HH, Lu SC, Chen YJ (2015). Revisiting the stability of mini-implants used for orthodontic anchorage. Journal of The Formosan Medical Association 114:1122-1128. (SCI)
- Chen YJ, Chang MC, Yao CCJ, Lai HH, Chang JZC and Jeng JH (2014). Mechanoregulation of osteoblast-like MG-63 cell activities by cyclic stretching. Journal of the Formosan Medical Association 113: 447-453. (SCI)
- Jenny Zwei-Chieng Chang, Wen-Chung Chang, Kuang-Ho Chen, Yunn-Jy Chen, Yi-Jane Chen, Hsiang-Hua Lai, Chung-Chen Jane Yao (2013). How to achieve proper overbite–Lessons from natural dentoalveolar compensation. Journal of Dental Sciences (in press). (SCI)
- Huang CT, Lai EHH, Chang HH, Chang BE, Chen YH, Wang YP, Chen YJ, Chang JZC, Yao CCJ (2012). Damage to the root after tooth movement towards a temporary anchorage device: An animal pilot study. Journal of Dental Sciences 7(2):171-78. (SCI)
- Chen SSH, Chang HH, Chen YH, Wang YP, Chen YJ, Lai HHE, Yao CCJ (2012). Tissue reaction surrounding miniscrews for orthodontic anchorage: An animal experiment. Journal of Dental Sciences 7(1):57-64. (SCI)
- Huang CH, Tseng WY, Yao CC, Jeng JH, Young TH, Chen YJ (2010). Glucosamine Promotes Osteogenic Differentiation of Dental Pulp Stem Cells through Modulating the Level of the Transforming Growth Factor-beta Type I Receptor. Journal of Cellular Physiology 225(1):140-51. (SCI)
- Kuo CC, Chen YJ, Lai EHH, Yao CCJ, Chang JZC (2009). Long-term stability of an adult Class III open-bite malocclusion treated with multiloop edgewise archwire. Journal of Dental Sciences 4(3):149-58. (SCI)
- Yang CM, Hsieh HL, Yao CC, Hsiao LD, Tseng CP, Wu CB (2009). Protein Kinase C-delta Transactivates Platelet-derived Growth Factor Receptor-alpha in Mechanical Strain-induced Collagenase 3 (Matrix Metalloproteinase-13) Expression by Osteoblast-like Cells. Journal of Biological Chemistry 284(38):26040-50. (SCI)
- Lai EHH, Yao CCJ, Chen YJ, Chang JZC (2008). Orthodontic treatment with a series of vacuum-formed removable appliances - case report. Journal of Dental Sciences 3(3):167-73. (SCI)
- Chen YJ, Chang HH, Lin HY, Lai EHH, Hung HC, Yao CCJ (2008). Stability of miniplates and miniscrews used for orthodontic anchorage: experience with 492 temporary anchorage devices. Clinical Oral Implants Research 19(11):1188-96. (SCI)