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Chun-Pin Chiang Emeritus Professor

Tel:886-2-23123456 ext 67407
Email:cpchiang@ntu.edu.tw


Experiences

B.D.S., Dentistry, National Taiwan University, 1977
D.M.Sc., Oral Pathology, Harvard School of Dental Medicine, 1989

 

Professional specialties

Oral Diagnosis

Main Research Interests

Immunohistochemistry for Oral Lesions

This study used monoclonal and polyclonal antibodies and immunohistochemical method to assess the expression of oncogenes, tumor suppressor genes, growth factors, growth factor receptors and cytokeratins in oral premalignant lesions, oral cancers, salivary gland tumors, odontogenic cysts, and odontogenic tumors. The expression of these particular proteins was further correlated with oral habits, clinical parameters (patient's sex, age, tumor location, tumor size, lymph node metastasis, clinical staging), and histopathological parameters by statistical analysis. This study will help us to understand the malignant potential of oral premalignant lesions and the mechanisms of the development of oral lesions.

Photodynamic Diagnosis and Treatment of Oral Precancers and Oral cancers

Recently, we develop autofluorescence and ALA-induced protoporphyrine IX (PpIX) fluorescence spectroscopy to diagnose oral precancers (OPC) and oral cancers (OC). By means of autofluorescence spectroscopy at 330-nm excitation and ALA-induced PpIX fluorescence spectroscopy at 410-nm excitation, we can differentiate among oral submucous fibrosis, normal oral mucosa, OPC and OC. Therefore, autofluorescence and ALA-induced PpIX fluorescence spectroscopy can be used to determine the appropriate sites for biopsy in a large leukoplakia or erthroplakia lesion. In addition, the photodynamic therapy (PDT) with topical application of 20% ALA (topical ALA-PDT) can be used to treat OPC and OC. Our results indicate that topical ALA-PDT is very effective for treating verrucous hyperplasia and erythroleukoplakia and has a high potential to be used for treating verrucous carcinoma and early invasive squamous cell carcinoma.

Selected Publications

     
  1. Sun A, Chang JYF, Wang YP, Cheng SJ, Chen HM, Chiang CP (2016). Do all the patients with vitamin B12 deficiency have pernicious anemia? Journal of Oral Pathology & Medicine 45:23-7.(SCI)
  2. Sun A, Chang JYF, Chiang CP (2016). Blood examination is necessary for oral mucosal disease patients. Journal of the Formosan Medical Association 115:1-2.(SCI)
  3. Cheng SJ, Chen HM and Chiang CP (2015). Cryogun cryotherapy is the first-line treatment of choice for oral leukoplakia. Journal of Dental Sciences 10: 223-224. (SCI)
  4. Chiang ML, Hsieh YJ, Tseng YL, Lin JR and Chiang CP (2014). Oral mucosal lesions and developmental anomalies in dental patients of a teaching hospital in Northern Taiwan. Journal of Dental Sciences 9: 69-77. (SCI)
  5. Shen WR, Wang YP, Chang JYF, Yu SY, Chen HM and Chiang CP (2014). Perineural invasion and expression of nerve growth factor can predict the progression and prognosis of oral tongue squamous cell carcinoma. Journal of Oral Pathology & Medicine 43: 258-264. (SCI)
  6. Sun A, Lin HP, Wang YP, Chen HM, Cheng SJ, Chiang CP (2013). Significant reduction of serum homocysteine level and oral symptoms after different vitamin supplement treatments in patients with burning mouth syndrome. Journal of Oral Pathology & Medicine doi: 10.1111/jop.12043 (SCI)
  7. Cheng SJ, Liu YC, Cheng SL, Lee JJ, Chen HM, Chang HH, Kok SH, Kuo MYP, Chiang CP (2013). Expression of G�12 predicts progression and prognosis of oral squamous cell carcinomas in Taiwan. Journal of Oral Pathology & Medicine  DOI: 10.1111/jop.12050. (SCI)
  8. Lee JJ, Cheng SJ, Wang YP, Jeng JH, Chiang CP, Kok SH (2013). Osteonecrosis of the jaws associated with the use of yearly zoledronic acid: Report of 2 cases. Head & Neck 35(1):E6-E10. (SCI)
  9. Cheng SJ, Kok SH, Lee JJ, Kuo MYP, Cheng SL, Huang YL, Chen HM, Chang HH, Chiang CP (2012). Significant association of SRC protein expression with the progression, recurrence, and prognosis of oral squamous cell carcinoma in Taiwan. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 34(9):1340-45. (SCI)
  10. Sun AD, Lin HP, Wang YP, Chiang CP (2012). Significant association of deficiency of hemoglobin, iron and vitamin B12, high homocysteine level, and gastric parietal cell antibody positivity with atrophic glossitis. Journal of Oral Pathology & Medicine 41(6):500-04. (SCI)